Clinical Applications of System Regulation Medicine

The Human Thioredoxin System: Modifications and Clinical Applications

The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. Trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( Trp-Cys-Gly-Pro- Cys-Lys-). Different factors are involved in the regulation of T...

Savill's System of Clinical Medicine

Savill's System of Clinical Medicine

Should the contents of a textbook of medicine be arranged according to structure or function in human illness? Since "diagnosis"-a central focus of medical reasoning-is often based on the terminology of morbid anatomy, a structural organization of the text would classify disease according to pathologic derangements. A functional classification would be based on clinical manifestations, which re...

Clinical applications of retinoids in cancer medicine.

The retinoids are compounds structurally related to vitamin A. The most extensively studied agents in cancer medicine include all-trans-retinoic acid, 9-cis-retinoic acid, and 13-cis-retinoic acid. In addition to several described immune regulatory functions, these agents may exert their antineoplastic effects through the regulation of tumor suppressor genes such as RAR-beta2. The survival bene...

Some Applications of Physics to -clinical Medicine

RECENTLY Dr. Alex Comfort (I963) has referred in a particular context to the 'irruption of the physicist' into the medical field. Although his entry has been generally less dramatic than this would suggest, the physicist is increasingly to be found in the membership of clinical departments and research teams. Most teaching hospitals and many other large hospitals have physics departments and th...